Demareed++Adenosine+Deminase+(ADA)+Deficiency

Adenosine Deminase (ADA) Deficiency Adenosine Deminase Deficiency or ADA is one form of SCID. Being that ADA is very rare it can be very critical. It is hard to tell if someone has ADA because it a an internal type of disorder that affects the immune system. When being infected with the deficiency, the immune system is open to bacteria and viruses.
 * Description: **

ADA deficiency is an autosomal recessive disorder. That means both parents need to pass the gene to their child in order for that child to have the deficiency.
 * Inheritance: **

The symptoms of ADA are that the immune system malfunctions, in which people who have the disorder are more susceptible to all kinds of infections, particularly those of the skin, and respiratory system.
 * Symptoms: **


 * Daily Life: **

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 * Diagnosis: **

ADA is diagnosed by doctors who can identify ADA during the mother’s pregnancy. They do that by taking a tiny sample of tissue from the amniotic sac where the baby. They also diagnose it by looking at enzyme levels in a small blood sample from the umbilical cord.

ADA disorder is not treated but doctors have tried to restore the ADA levels and improve immune system function with a variety of treatments: > Doctors used to use bone marrow transplants. But one of the more effective, is to injectchemically treated form if ADA, called PEG-ADA into the blood of a child with ADA deficiency.
 * Treatment: **
 * Bone marrow transplants
 * Transfusions of red blood cells
 * <span style="color: black; font-family: Times,serif; font-size: 12pt;">Enzyme replacements
 * <span style="color: black; font-family: Times,serif; font-size: 12pt;">Gene Therapy
 * <span style="color: black; font-family: Times,serif; font-size: 12pt;">Research: **

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 * <span style="color: black; font-family: Times,serif; font-size: 12pt;">Additional Facts: **
 * <span style="color: black; font-family: Times,serif; font-size: 12pt;">ADA deficiency is extremely rare. In the United States each year only about 10 to 20 children are diagnosed with ADA.
 * <span style="color: black; font-family: Times,serif; font-size: 12pt;">In 1990, doctor William French Anderson, Michael Biase, and Ken Culver preformed the first successful gene therapy on Ashanti de Silva, a young girl with ADA deficiency.
 * <span style="color: black; font-family: Times,serif; font-size: 12pt;">Punnett Square: **

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 * <span style="color: black; font-family: Times,serif; font-size: 12pt;">Pedigree Chart: **

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 * <span style="color: black; font-family: Times,serif; font-size: 12pt;">Resources: **

<span style="color: black; font-family: Arial,sans-serif; font-size: 10pt;">Utah University, <span style="font-family: Arial,sans-serif; font-size: 10pt;">[] <span style="color: black; font-family: Arial,sans-serif; font-size: 10pt;">, ADA, Learn Genetics, 2011, 5/20/11 <span style="color: black; font-family: Arial,sans-serif; font-size: 10pt;">Bryan Bunch and Jenny Tesar, Diseases volume 1, Danbury, CT, Scientific Publishing INC., 12-13, 2006